is anyone looking to be able to measure glycated insulin? Glycation (sometimes incorrectly called non-enzymatic glycosylation) is the covalent attachment of a sugar to a protein or lipid. Typical sugars that participate in glycation are glucose, fructose, and their derivatives.
Most monosaccharides, including glucose, galactose and fructose, spontaneously bond with hemoglobin, [hgAc1]when present in the bloodstream of humans. Glycohemoglobin, hemoglobin A1c provides a three (3) month average of fasting glucose levels.
My hypothesis is the glycation of insulin is mainly responsible for cell's resistance to insulin
Is there a standardized laboratory test for glycated insulin?
It is an interesting question but I have not heard of such test. If it dives indication of Insulin resistance, then it would be useful.
Thank you, Emad - the identifying procedure could then lead to discovering the process or pathway of protein glycation, especially in the brain
Glycated insulin can be determined by several methods.
Please see the following link:
https://diabetes.diabetesjournals.org/content/52/2/492
See also the following link:
https://www.rndsystems.com/resources/articles/glycated-insulin
Also, the following article may be helpful in this regard:
Article Glycation and Insulin Resistance Novel Mechanisms and Unique Targets?
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