It hasn't been thoufht of before I guess, but it could be a Bartonellosis. B

henselae has a strong angiogenic machinery and can hijack or even chane the human genome. BH causes teleangectasias and bacillary angiomatosis but as I read about AVM of brain which were highly imflammatory and lethal etc. I think ther are plenty of other vascular tumors from BH. Diagmosis is.often impossible But Rifa with Minocyclin or Azithromycin works f not mino is antiangiogenic. .

Thank you very much for your answer. This is something which I have learned from you and I should consider this possibility as I am desperate right now without any solution for my young patient.

Maybe it's worth having a close look at her left foot nails. Nailfolds have "bad" defences because they are "immune privileged" antennae of the immune system (lymphatics). In my patiens I found several opportunistic germs Pantoea, Acinetobacter, Torphomonas etc. - there also could be some molds, which seem to be very resistant. It is further reasonable to suspect a mast cell activation, and mast cells could be the source of too much VEGF. Does she have dermographism, diarrhea, anaphylaxia, sudden vegetative crises etc. (see. Mast cell activation syndrome). Desloratadine 5mf ( 2x2) could be of help. Essential oils thymian or better cardamon, perhaps cinnamon can be used locally with good but transient results. If fungi combine with antifungals, if bacteria wit e.g. Rifa/Mino or Azithr. which are active against intracellular germs. at the same time be careful with the microbiome...

"Alternatively" one could consider transfusions with a plasma fraction enriched with alternatively spliced VEGF receptor-2 if that is feasible.

Lit2:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882165/

http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20961309/

Lit: Microvasc Res. 2010 Sep;80(2):195-201. doi: 10.1016/j.mvr.2010.04.002. Epub 2010 Apr 9.

Multiple expressions of lymphatic markers and morphological evolution of newly formed lymphatics in lymphangioma and lymph node lymphangiogenesis.

Ji RC1, Eshita Y, Xing L, Miura M.

Abstract: The rapid evolution of reliable technology combined with increasing number of specific markers for lymphatic endothelial cells (LECs) facilitates the investigation of lymphangiogenesis in developing and diseased tissues. Here, we injected incomplete Freund's adjuvant (IFA) peritoneally into BALB/c and nonobese diabetic (NOD) mice to induce lymphangioma and found atypical lymphatic accumulations with intervening fibrous tissue and lymphoid aggregates. Lymphatic markers, LYVE-1 and podoplanin, were used to specifically define the morphological features of the neoplastic lymphatics. The NOD mice (affected by an autoimmune disorder) had fewer and smaller lymphangiomas than the BALB/c mice. Injection of IFA in the footpad skin of the mice also disturbed draining regional lymph node lymphangiogenesis and caused enlargement of popliteal lymph nodes. Molecular analyses of the LECs indicated potential interventions for lymphangioma through vascular endothelial growth factor (VEGF)-A/-C/-D and their receptors, VEGF receptors-2/-3, and Prox-1 signaling pathways.

and then one could consider creating a source of IL-1b at the foot nails... via LPS - can be augmented with colchicine all to increases miRNA1236 which blocks VEGFR-3 Only).

Lit.: http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=22223733

:-)