I used Arena by Rockwell Automation for some didactic exercises tailored to manufacturing engineering students.
It has great capabilities for modeling complex systems in a relatively short time, especially thanks to built-in functions and sub-models in its library, which you can use as building blocks of more complex models.
However, as pointed out by some users who are way more experienced than myself in modeling and simulation, Arena has poor a input data analyzer if compared to the one of other competitive software like Flexim, for instance. (Note: you use the input data analyzer to test the fitness of distributions from data points).
Another weakness is visualization: you have to insert commands for creating a visual model in a separate step from the commands that create the logic model. This does not happen in software which have drag-and-drop functions of entities (e.g., machines, people).