What is this? Have you seen similar?
Avian embryos were exposed to hepatocarcinogen diethylnitrosamine. Cell isolation by collagenase. In culture, over time, these “monsters” appear. Although by now the focus of my work has shifted to the regulatory world, i.e. getting new medicines authorized, I still wonder what this is.
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And if you are more interested in innovative cancer medicines getting approved in Europe, have a look at European Regulatory Oncology News https://ogy.de/eron-11-22
This is either liver parenchyma giant cell hepatitis, resulting from hepatocyte fusion, or a multinucleated giant cell formed by macrophage fusion. https://www.sciencedirect.com/science/article/abs/pii/S0016508519321432
Article Giant-cell Hepatitis-Rare Entity in Adults
Article Histopathology of granulomatous liver disease
Thanks! I was not aware of Giant cell hepatitis - occuring in mostly neonates. Occuring "in response to a variety of insults" fits perfectly!