What sort of compound are you extracting? This makes a big difference. For example, alkaloids can generally be extracted as the free base if the aqueous layer is made basic. The free base usually partitions into the organic layer and recovery is higher when the aqueous layer is basic. It won't work for acidic compounds!

"Salting" the aqueous layer also tends to force organic molecules into the organic layer too.

It's a non Polar secondary metabolite from microbial species.

In this case, the organic solvent might be optimized. Hexane, ethyl acetate, dichloromethane, ether...

That's probably as good as you'll get without more detail. Also consider solid phase extraction.