Excellent article, which shows preference of high dose IM over transplantation in pediatric CML specifically.However, side effects of high dose IM are not mentioned in abstract, if any. Can you elaborate safety and tolerability of high dose IM in children studied? Moreover, what maximum higher doses of IM can be used in children safely? Actually, I was discussing with Prof Saglio about higher IM doses in ped ALL (Ph+) as it is represented in about 25-45% of Pakistani ALL patients. Your answer will help me understand its feasibility.

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