As the title says I am an engineer and happen to be working in the cancer domain specifically TNBC. I am working on a research project where I am trying to understand the signaling pathways activated in TNBC stem cells, due to my limited knowledge in this field I am having difficulties finding answers to some probably very dumb questions which I have listed below. Your answers and feedback are greatly appreciated.
TNBC, HER2+ are different sub-types with different signaling pathways (though most pathways in all cancers are common). Since they are 2 different subtypes based on the presence or absence of different protein/receptors their signaling mechanism will be different.
when you talk about BCSC you need to specify the source, which is important.
the patient can have low HER2+ and TNBC (is another emerging sub-type within TNBC and have a low level of HER2+), so it is possible.
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