I am about to reconstruct a metabolic network for a chemelithiautotroph thiobacillus. It uses Co2 as the carbon source and Thiosulfate as the energy source. I have setted a central metabolsim for this micro organism inculding Calvin cycle (The dark part), TCA cycle, Glycolysis and other common pathway but when in comes to sulfur metabolsim in which Thiosulfate is consumed and terationathe is produced then terathionate oxidizes and so on. When I add sulfur metabolsim network become infeasible and there is no link between central metabolsim and sulfur. I'd be very thankful if anyone could help me.