You know there are some important factors we have to keep in our mild before planning a research proposal like rate / frequency of a disease, availability of investigation support, duration of study period and budget also. Like doing a RCT has a strong research value but requires time and fund on other hand doing observational ( acutely less to distinct as research) requires less supports for example : outcome and complications during indication phase or outcome of febrile neutropenia or act on other possible complications like frequency of hyperglycemia or coagulopathy or hyperglycemia or hypertension or nutritional status; even doing study on genetic records like pattern of cytogenetis or TPMT analysis in comparison of 6MP/ MTX dosing.