Drugs /drug candidates with poor water solubility

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How do clinical researchers measure transference in psychotherapy patients/clients?

I have a hypothesis that the ceiling effects that appear on measures of the working alliance may be related to positive transference by patients/clients. But when I look into the research...

28 December 2023 4,740 7 View

Which statistical analysis to use for agreement of measurement in count data?

Hello, For my research, I want to know if there is measurement agreement between to tests that I performed. The tests are both performed once, and the outcomes of the tests are count data. I...

02 May 2023 6,019 1 View

Can anyone suggest me a topic for my bachelor thesis in Supply Chain Management (SSCM/Technology/China)?

Hello everyone, I am currently looking for a topic for my bachelor thesis. I would like to combine the two major topics of Sustainable Supply Chain Management and the use of disruptive...

04 October 2021 6,697 5 View

Recommended critiquing tool for a literature review analysing Mixed Methods/Mixed Studies please?

Hi all. We are conducting a systematic review looking at varies research designs, some mixed methods and mixed studies. Through previous experience the MMAT is applicable Microsoft Word -...

10 June 2021 4,882 5 View

Any experience with why high instrument-to-instrument variability using two HIAC instruments ?

My instruments are not giving similarly SVP results

29 December 2020 4,778 1 View

Can you have all random effects in a linear mixed model?

I am doing a repeated measures analysis on global longitudinal strain data from echocardiography. I am using a LMM to analyse the variance components, as there was some missing data on patients...

13 September 2020 3,276 1 View

Has anyone done a study on preventative health care or not in Micronesian people groups?

I'm interested in prevantative vs. reactive health care practices of Marshallese people in Hawaii. In regards to the UH study of 2015 about "Younger and Sicker, Micronesian vs. other ethnic...

20 July 2020 6,136 0 View

Entrepreneurial Orientation Measurement Results?

Hello, I am looking for a review of EO measurement results via the Miller/Covin Slevin scale. I mean the actual values for innovativeness, risk and proactiveness. There are a number of papers who...

18 November 2019 8,753 3 View

Paper describing the shape of an oil droplet on water?

i try to simulate the shape of a 100 microliter olive oil droplet on water. looking at the interfacial tensions of the system (approx. values from varoius papers: water-air 72mN/m, oil-air...

17 November 2019 9,456 3 View

What strategies have you used for recruiting study participants on a limited budget?

In my experience, recruiting study participants is one of the most challenging steps in the early stages of a research project. In the past I have typically distributed recruitment flyers that...

02 August 2019 4,232 5 View

• What the possible Persistent Organic Pollutants and Heavy metals present in fluorspar, sediments, and water bodies around its mining area?

Approximate concentrations are require in compared with the WHO permissible limts

11 August 2024 2,723 1 View

Handling Missing Data and Building a Predictive Model with Incomplete Information ?

I am developing a predictive model for a water supply network that involves 20 influencing points. However, I only have historical data for 10 out of these 20 points. I would like to know how to...

10 August 2024 4,005 2 View

Do interactions between biosphere, carbon cycle, & water cycle impact global warming & interaction between atmosphere & hydrosphere?

How do interactions between the biosphere, the carbon cycle, and the water cycle impact global warming and interaction between the atmosphere and the hydrosphere?

09 August 2024 3,291 2 View

Is it true that $\det(V(A))$ may be only $\pm 1$, depending on $n$, for the last symmetric tridiagonal matrix $A$?

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08 August 2024 6,690 1 View

Is changing the medium during the experiment overestimate the results?

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07 August 2024 2,283 2 View

What is saturation solubility of insulin in saliva?? I need it to know sink condition ?

05 August 2024 4,407 0 View

How to Add Missing Water Molecules in Protein-Membrane Simulations?

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04 August 2024 1,200 2 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

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03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

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03 August 2024 2,730 1 View

Why is nonpoint source pollution potentially more harmful and difference between point and nonpoint sources of water pollution?

01 August 2024 1,180 2 View

Isam Eldin Hussein Elgailani

Please look at the following below links which may help you in your analysis:

https://www.ispe.gr.jp/ISPE/02_katsudou/pdf/201304_en.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399483/pdf/ISRN.PHARMACEUTICS2012-195727.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/pdf/main.pdf

Thanks

Andrei Blasko

Look at www.clinicaltrials.gov and search for rejected NDA's.