Does there an analytical method using HPLC for quantitation and separation of ciprofloxacin and levothyroxine?

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Bruce Neagle

Yes. As I recall it is about 50/50 Metanol/pH 3 Phosphate Buffer. Detection is a PDA/DAD and column is a 10 cm C18 ODS. However, the results (concentration) depends on your sample matrix (drug substance, dosage form...).

Isam Eldin Hussein Elgailani

Please look at the following below links which may help you in your analysis:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293686/pdf/IJPhS-76-541.pdf

https://www.tandfonline.com/doi/pdf/10.3109/14756360903373350

https://dalspace.library.dal.ca/bitstream/handle/10222/65293/Anand-Utkarshini-MSc-PHAS-August-2013.pdf?sequence=1&isAllowed=y

Thanks

Afroza Begum

You may follow this article. It is much helpful.