Does the PFMs/PWMs (PSSM) have direction? Can it be inverted?

Adolfo Flores Saiffe @Adolfo-Flores-Saiffe

16 October 2013 0 7K Report

JASPAR db align TF PFMs to a sequence and its reverse, but not the inverted seq.

Badges
Science method

More Adolfo Flores Saiffe's questions See All

Is it possible to improve the reforming section of the Haber-Bosch process without using air separation units?

A typical reforming section in a large-scale Haber-Bosch process (Figure 1) comprises two reactors. A mixture of methane (CH4) and steam (H2O) is fed into a primary reformer to produce syngas via...

01 August 2024 7,051 5 View

Is there a plugin for weka to read *.sav files from SPSS?

Hello there. Several references say that there is a reader for .sav files from SPSS in Weka, but I just can´t find it. Can anyone provide help? Thanks in advance

12 June 2024 3,844 2 View

My publications are linked to another person. How can I correct this?

I just joined to ResearchGate but I realized that several of my publications are linked to other "Marcos Andrade (Universidade Presbiteriana Mackenzie)". Please help me claim my work

14 May 2024 1,053 1 View

Is there any real advantage in co-electrolyzing CO2 and H2O in liquid phase to produce syngas versus using separated electrolysis of H2O and CO2?

Electrochemistry is a pathway to convert CO2 into valuable products such as CO. However, a potential side product in the cathode is H2. I wonder if it is possible to tune the composition of the...

12 May 2024 9,061 3 View

Could anyone share their experience in designing small laboratories for immunobiologic for preclinical trials that comply with GLP/GMP standards?

Literature on the above subject will be welcomed

05 May 2024 1,099 1 View

What are the factors regarding sample quality or preparation variations that affects the results of Sysmex DI-60?

Although Sysmex DI-60 is a fully automated analyzer, further understanding and analytical processes to ensure the reliability of its functionality are needed concerning the factors and their...

11 April 2024 9,637 1 View

How can regional antibiograms in diagnostic microbiology help slow down antibiotic resistance?

I would like to know the importance of regional antibiograms as public health tools to combat antibiotic resistance, specifically, how regional antibiograms are generated, utilized, and help with...

11 April 2024 1,512 3 View

How does total assay time of DI-60 impact laboratory workflow efficiency and what strategies can be implemented?

I want to know more about how the Total Assay Time of Sysmex DI-60 impacts laboratory workflow efficiency compared to other automated analyzers, and what strategies can be implemented to optimize...

11 April 2024 3,844 0 View

Can pulsed electric fields be used to generate heat?

Pulsed electric field is considered a "non-thermal" method for food processing that involves the application of short high-voltage pulses to create pores in cell membranes. However, since I am not...

13 March 2024 2,624 6 View

How to dissolve Potassium Clavulanate in MES buffer or water?

I read that potassium clavulanate is water soluble. I tried to dissolve it to a very low concentration but the liquid remains cloudy and a white powder is visible at the bottom of the vial

06 March 2024 8,900 0 View

any study on protective factors of care givers of dementia and resilience ?

need to review articles on care giving in dementia and challenges faced

12 August 2024 6,424 1 View

The Optimal Experimental Approach for Gene Function Analysis?

What is the most suitable experimental setting to understand the consequences of a particular gene: (1) targeted degradation of the specific transcription factor (TF) of the gene, followed by...

04 August 2024 6,265 1 View

Which is more important: The human factor or the technological factor in combating climate change?

On a personal note, even though technology has attracted a lot of interest and funding to combat climate change, it is becoming more and more clear that taking care of the "Human Dimension" is...

02 August 2024 6,773 12 View

How to we see transcription activity of the bhlh79 family is at the N-terminal or C-terminal?

I'm a PhD Student. From Northwest Agriculture and Forestry University China. My Problem is this I start my work on bhlh79 transcription factor gene. I do my Y2H 5 time but the colonies appear on...

30 July 2024 1,412 8 View

ANCOVA for between-subject design?

Hi, I will run an experiment where reaction time will be the dependent variable, tested in 2 conditions (with the same participants). I want to control for a confounding variable (individual...

20 July 2024 1,943 1 View

What happens in snapTotal- seq?

What happens in snapTotal- seq? (Single-cell Total-RNA Profiling Unveils Regulatory Hubs of Transcription Factors https://www.nature.com/articles/s41467-024-50291-3) In this protocol, several RT...

18 July 2024 10,010 0 View

How to decide whether the refinement is correct or not, based on Rwp and Rexp factors by Fullprof?

One of the papers I read by Toby, where (title of the paper was "R factors in Rietveld analysis: How good is good enough?"), he tells us that to get good chi square value, you must have low Rwp,...

17 July 2024 9,668 4 View

How can the economic value of digestate management, utilization, and regulation, can spark interesting discussions and explorations?

How can the economic value of digestate management, utilization, and regulation, can spark interesting discussions and explorations? so one can list down the details and we can discuss in length...

17 July 2024 3,255 4 View

Does the bread-making process lead to a sufficient reduction in lectin activity of bean flour to guarantee food safety?

I'm currently working on the implementation of pulses (legumes) in bakery applications. In one case, pulse flours could be added to bread to increase the nutritional value. Pulses (in particular...

17 July 2024 7,293 3 View

Is it possible to generate a (semi-)permanent "transcription bubble" within a replicable plasmid?

I was wondering if it is possible to form a permanent open "ssDNA bubble" similar to a transcription bubble (>13 nucleotides) within E. coli. These criteria are important: 1. Open ssDNA...

07 July 2024 8,275 5 View