Many mitochondrial proteins are encoded by the nuclear genome. Do different cell types supply the same set of proteins to their mitochondria? Or do different cell types fine-tune mitochondrial function to suit their own physiological function?
Hello Robert D Phair
Cell-type specificity of mitochondrial dynamics could be related to specific cellular functions and demands, indicating a significant role of integrations of mitochondria with other intracellular systems like the cytoskeleton, nucleus, and the endoplasmic reticulum (ER).
You could refer to the article attached for more information.
Article The cell-type specificity of mitochondrial dynamics
Best.
Malcolm Nobre,
Thank you for taking the time to answer my question. I agree that the Kuznetzov review recounts evidence for cell-type-specific fission, fusion, and positioning of mitochondria.
At the next level of detail, we could ask, "Are the mitochondria, themselves, provisioned with different proteins in different cell types?" Because so many mitochondrial proteins are encoded in the nuclear genome, there is some ambiguity in my use of the phrase, "mitochondrial proteome," but what would you answer if I instead asked, "Does the list of proteins with mitochondrial targeting sequences differ by cell type?"
Regards,
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