I am curious about where to submit my manuscript. If I go with how well my work fits with specialized journals in the field I end up losing my chances for the big names. But do these big names or to quote the right words "high Impact" journals really make a difference these days or the trend is now changed? I happen to come across so many success stories in my circle about post doc positions, grants, promotions most of them linked to these guys publishing some Science or Nature papers. Are we really making an 'impact' with these high 'impact factors'?