we observed BMP expression in bulb and bulge area after a drug treatment and also Beta-catenin expression did not increased in bulge or bulb in comparison to control.
also, we showed that Kras/Erk1 signaling pathway is activated and Shh gene expression were increased. Among the BMP, Kras/ERk1 and Shh, it is Shh that more expressed in bulb and bulge after drug treatment.
it seems that Kras/ erk1 signaling pathway correlated with cell survival, and also Shh over expression indicative of cell survival in bulb and bulge, but when we did not see beta catenin over expression, if can we conclude the drug caused anagen or cell survival after 7 day drug treatment?
we cant conclude about this results. could you help me?
I think that your explanation is logically correct.
But I recommend you that nuclear Gli-1 as well as nuclear beta-catenin should be evaluated by F-IHC.
In my opinion, Shh that more expressed in bulb and bulge after drug treatment. As you know well, Shh hyperactivation is responsible for the development of basal cell carcinoma (BCC) derived from proliferative hair germ cells.
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