Dear Kira

I am slightly confused with your question. Please clarify. Do you think it is the high dose GCSF causing immune tolerance or the granulocyte infusion itself (because it contains lots of lymphocytes) and what exactly you mean by immunetolerance?

Regards

Siva

good day

very good question ,as one thinks that this growth factor will activate auto immunity ,really they can augment immune modulation ,as i used in few cases of organ specific auto immune disease like in multiple sclerosis,,but we need to know the pathophysiology?

HI Kira

in my limited experience i used G-csf for stem cell mobilization to be used for immune modulation specially in auto immune diseases like in systemic lupus and i noticed an improvement that could be related to immune tolerance, i agree with you but what is the mechanism? and how can we procced/

Hi there,

thank you for your answer and sorry it took me so long to reply. I heard of the mechanism you are describing and read some paper discussing their experiences about inducing immunotolerance to treat auto-immune diseases. I think that this might be a promising therapeutic option for patients who do not respond to established therapy. However, my question related to another group of patients. Patients with haemato- oncological diseases are prone to infectious complications during the time of neutropenia. Granulocytetransfusion (GTX) is practiced at some medical centers as ultima ratio therapy to save their lives. In my thesis I analyzed the overall survival of patients receiving GTX. On first sight it seemed as if patients receiving high doses of G-CSF tend to have a lower overall survival – that was when I thought of the immunotolerance induction caused by G-CSF. However, in a subgroup analysis results showed that patients, receiving high doses of G-CSF tend to suffer from more serious infectious complications than patients receiving lower doses of G-CSF and that this is more likely to explain the lower overall survival than the immunotolerance induction.