In some studies we read that morphine and derivatives would have an agonist effect on GH release (but negative effect on thyroid hormones and ACTH), in other texts we learn instead that opiates affect with growth hormone depletion, while still other studies do not show any alterations to the GH-related parameter following administration of opioid agents.
Hi,
Here are a few references which could be of help to you:
Hashiguchi Y, Molina PE, Fan J, Lang CH, Abumrad NN. Central opiate modulation of growth hormone and insulin-like growth factor-I. Brain Res Bull. 1996;40(2):99-104. doi: 10.1016/0361-9230(96)00045-7. PMID: 8724426.
Barb CR, Kraeling RR, Rampacek GB. Opioid modulation of FSH, growth hormone and prolactin secretion in the prepuberal gilt. J Endocrinol. 1992 Apr;133(1):13-9. doi: 10.1677/joe.0.1330013. PMID: 1517702.
Guido M, Romualdi D, Mancini A, Lattanzi F, Villa P, Barini A, Lanzone A, De Marinis L. Effect of the opioid blockade on the feeding-induced growth hormone response to growth hormone-releasing hormone in women with polycystic ovary syndrome. Fertil Steril. 2002 Nov;78(5):994-1000. doi: 10.1016/s0015-0282(02)04201-2. PMID: 12413983.