Dear all,
How circadian rhythm change and sleep deprivation affects the brain? does both acts deferentially or same way on the brain and what are the consequences? which has more negative outcomes among both?
Thanks in advance for sharing your knowledge and greatly appreciated...
Dear Govindaraj
Circadian clock and sleep are not yet completely shown to be associated, but circadian rhythms output hormone melatonin have been shown to induce sleep in diurnal animals, including humans. But both circadian rhythm disruption and sleep deprivation affects the brain functions similarly. Main consequences include cognitive deficits like declined learning and memory, depression and anxiety. At molecular level it is difficult to say both acts similarly or not, but evidence from both nocturnal (rodents) and diurnal (humans, birds) like changes in neuropeptides, neurogenesis and maturation of neurons in are associated with both. Therefore, it can be suggested both circadian rhythms disruption and sleep deficits, independently or/and in associations affects the brain functions.
Thank you.
Taufique
a. Sleep is considered as a biological rhythm
b. There are over 90 types of sleep disorders. Sleep deprivation can occur for various reasons. It can be due to primary or a secondary disorder (co-morbidity)
c. The intensity and duration, and coping strategies varies among individuals.
d. Death is the ultimate consequence of total sleep or selective deprivation. So does the completely arrhythmic animals.
e. some of the clock genes are implicated in both in sleep and circadian rhythms. Melatonin is also involved in sleep and circadian rhythms.
Would you like to compare the effects of short-term (acute) sleep deprivation vs. chronic circadian desynchrony? Would you like to find out which one will have a detrimental effect?
Dear Dr. Seithikurippu R. Pandi-Perumal ,
Yes sir, I have to compare sleep deprivation vs circadian rhythm change and also i have to study which has more detrimental effect on brain among these.
Hi....
A recent paper came about the
"Mutual influence of sleep and circadian clocks on physiology and cognition".
Article Mutual influence of sleep and circadian clocks on physiology...
This might help.
Thank you.
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