We basically did infection modelling of TB in mice using clinical strains. we estimated bacterial load at 30 and 50 days post infection, Although CFU tires were evident at both time periods, we found levels of both antigen and antibodies toward 50 days with fewer titres at 30 days. what could be possible reason for this?
Dear Sir,
See these links may be useful for you.
1) Antibody Profiles Characteristic of Mycobacterium tuberculosis ...
iai.asm.org/content/73/10/6846.full Traduire cette page
de A Davidow - 2005 - Cité 112 fois - Autres articles
Antibodies to the 38-kDa antigen, alanine dehydrogenase, and Rv2626c were ... It was found that levels of transcripts encoding the six M. tuberculosis .... 16S rRNA levels correlate well with CFU during the course of lung infection regardless of ...
2) B Cells Regulate Neutrophilia during Mycobacterium tuberculosis ...
journals.plos.org/plospathogens/article?id=10...ppat... Traduire cette page
de L Kozakiewicz - 2013 - Cité 36 fois - Autres articles
11 juil. 2013 - Author Summary Mycobacterium tuberculosis poses a serious threat to public health globally. ... that regulate IL-17 levels and neutrophilia, may lead to the development of ... conjugated Ab were infected aerogenically with 200–300 CFU of M. ..... It is, however, possible that the antigen uptake and migration ...
3) Mucosal Immunology - Pulmonary M. tuberculosis infection delays Th1 ...
www.nature.com › Journal home › Archive › Articles Traduire cette page
de M Jeyanathan - 2014 - Cité 10 fois - Autres articles
30 oct. 2013 - Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) .... Results are expressed as mean±s.e.m. of colony-forming units (CFUs) from five to six mice per ... The level of Ag-specific Th1 cell responses in the lung was ..... using an anti-IL-10R antibody added to WT APCs and P25-Tg T-cell ...
Hi Ali
I would ask you any type of Mycobacterium used in your experiment?.and you should remember ,the cell-mediated immune response more effective than humoral immunity (Antibodies Production) in TB infection because the mycobacterium
Facultative intracellular chronic pathogen. Therefore the level of Abs not related with severity of the disease . The Antibodies used for Presence or absence of infection . you can use other Immunological parameter for follow up.
Antibodies elicited during earlier time points post-infection could be trapped in immune complexes. This would preclude detection of both antigen and antibody.
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Infectious Diseases