Plasma levels of LDL-Cholesterol ,small and dense LDL or Cholesterol rich- Lipoprotein remnants are in circulating blood. Its oxidative modification may affect endothelial cells by an interacction with them.The inflammatory response is parcially atributed to oxidation of LDL . Native , non-modified HDL can protect LDL from such oxidation. This process may be active in all tissues.

Dietary cholesterol do not significant increase lipoprotein-cholesterol plasma levels.

That sounds great, thanks for your answer!

I'm supposing that the same mechanism of oxidation will lead a BBB breach to the LDL into the brain, do you know any reference for this?

I also have read something about LXRs, and inflammatory responses caused by high cholesterol levels, but these mainly explain systemic mechanisms and/or so little of GM, but I suppose that the cholesterol metabolism by the oligodendrocytes that produce oxysterols could also cause somehow reactivity or neurotoxicity and thus inflammation and that with enough time can be related to demyelination. But this is just my hypothesis. Because many papers said that almost all cholesterol products cannot cross the BBB, but LDL and HDL, but still they don't explain how these last two can cause neurotoxicity or neuroinflammation on WM.