http://www.sciencemag.org/content/342/6161/983.long#F2

Published Online October 24 2013

Science 22 November 2013:

Vol. 342 no. 6161 pp. 983-987

DOI: 10.1126/science.1245296

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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons

Thanks for the answer. I had a quick look to the paper, but I could not find a precise estimate of alpha-synuclein concentration in neurons. Could you provide this number?

Anyway, I will read it more carefully during the week end and I will look also at the Supplementary materials. Thanks again.

another one, some numbers from ELISA and histopathology data http://www.sciencedirect.com/science/article/pii/S0014488608002562

or you can contact directly

Prof. Tiago Fleming Outeiro

Phone: ++49-551-3913544

Fax: ++49-551-3922693

e-mail: [email protected]

http://www.neurodegeneration.uni-goettingen.de/index.html?en/p211.html

According to this paper, it's 6uM: http://www.sciencedirect.com/science/article/pii/S0092867412004710

Thank you very much for the reference. I had a look at the reference provided in the paper you cited and it seems that this estimate comes from western blot analysis or something like that. I think that this is not the best method to evaluate alpha-synuclein concentration in neurons. But this result is what can be found in the literature. Therefore, thank you very much for your reply.

Should you send me the paper please i dont have account and i need to read it as i am running a model of PD with rotenon now. and have a problem as i have a high mortality rate with 1.5mg/kg rats PEG:DMSO 1:1