Glucocerebrosidase (GCase) is a lysosomal enzyme (EC 3.2.1.45) encoded by GBA gene and responsible for the hydrolysis of glucosylceramides, an intermediate in glycolipid metabolism. The resulting products are glucose and ceramide molecules.
I can't find any report about the inhibition of its enzymatic activity by iits products (i.e. by ceramides). Do you know more?
Adam B Shapiro
There is a report of weak inhibition of the human enzyme by glucose:
http://brenda-enzymes.org/literature.php?e=3.2.1.45&r=136471
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Nicoletta Plotegher
Thank you Adam! And thank you for the website... I did not know about this Brenda and it seems really useful.
Weak inhibition by glucose but nothing was reported for ceramides. Probably it is also not that easy to test...
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