Hello dear masters and colleagues,
I have two question about T. gondii :
1- Why this parasite is an obligate intra-cellular one, despite of having mitochondrial enzymes, golgi body, ribosomes and endoplasmic reticulum?
2- Why T. gondii does not infect the Red Blood Cells?
with regards.
Hi my dear. I think it is a method of parasite scape of immune system of the host. But independet of host's organelles.
Hi Mr. ; hereby my lecture on T. gondii could be helpful ; and about does not infect the R.B. C. , I think it is a matter of Host-Parasite relationship and evolution ; Thanks
It depends on the host for many metabolites (e.g. purine auxotroph)
Dear Hamidreza:
1. From my point of view, Toxoplasma can not synthesize some of the co-enzymes that are required for biochemical activities of the key enyzymes by it's own, such as Co-A, which participate in about 4% of all biochemical reactions in the body, so they need to obtain these requirements from the host.
2. Red blood cell is not an identical place for the parasite to hide compare to the tissues, as it can be easily destroied by the immunity system. Therefore, when the immunity system of the host become waek (for many reasons) the parasite changes into tachyzoites and inter the blood stream not RBC, so they can easily reach the target organs. While when the immunity system reactivate, the parasite escape rapidly into the tissues, where the immunity system find difficulty to chase the parasite.
Regards
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