CD44s has a molecular weight of around 84kDa. Its variant usually has a higher molecular weight. Conversion of 1-742 amino acid of CD44 mRNA gives the mass of 84kDa. This full length includes the variants exon (if I am correct). Since the variants region are not encoded in CD44, but only in CD44v, how does the CD44 have a molecular weight of 84kDa? How can the CD44v have a mass that is more than 84kDa? Does the glycosylation and other modification account for the CD44v mass more than 84kDa?
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Variant exon-encoded region of CD44 adhesion molecule is easily to undergo glycosylation, which increases the molecular weight of CD44 in Western blotting up to 150-200kDa. Squamous cancer cell lines tend to show significant glycosylation pattern, as Yoshikawa et al. have demonstrated in Cancer Research.
Further, as far as I know, CD44s corresponds to 85kDa, while CD44v8-10 to 120kDa even without post-translational regulation such as glycosylation.
If you want an updated view on CD44s, CD44v and HA receptors in general, from a biological and material scientist perspectives, please have a look at our latest review.
Kind regards,
Julio.
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