Dear Gregory S Cantrell

perhaps the (partly older) literature can help - at least to avoid to reinvent the wheel:

1: Squintani G, Donato F, Turri M, Deotto L, Teatini F, Moretto G, Erro R.

Cortical and spinal excitability in patients with multiple sclerosis and

spasticity after oromucosal cannabinoid spray. J Neurol Sci. 2016 Nov

15;370:263-268. doi: 10.1016/j.jns.2016.09.054. PubMed PMID: 27772772.

2: Ayromlou H, Mohammad-Khanli H, Yazdchi-Marandi M, Rikhtegar R, Zarrintan S, Golzari SE, Ghabili K. Electrodiagnostic evaluation of peripheral nervous system changes in patients with multiple sclerosis. Malays J Med Sci. 2013

Jul;20(4):32-8. PubMed PMID: 24043994; PubMed Central PMCID: PMC3773350.

3: Stein RB, Everaert DG, Roy FD, Chong S, Soleimani M. Facilitation of

corticospinal connections in able-bodied people and people with central nervous

system disorders using eight interventions. J Clin Neurophysiol. 2013

Feb;30(1):66-78. doi: 10.1097/WNP.0b013e31827ed6bd. PubMed PMID: 23377445.

4: Sosnoff JJ, Motl RW. Effect of acute unloaded arm versus leg cycling exercise

on the soleus H-reflex in adults with multiple sclerosis. Neurosci Lett. 2010 Aug

2;479(3):307-11. doi: 10.1016/j.neulet.2010.05.086. PubMed PMID: 20570604.

5: Motl RW, Snook EM, Hinkle ML, McAuley E. Effect of acute leg cycling on the

soleus H-reflex and modified Ashworth scale scores in individuals with multiple

sclerosis. Neurosci Lett. 2006 Oct 9;406(3):289-92. PubMed PMID: 16916583.

6: Magistris MR, Rösler KM, Truffert A, Landis T, Hess CW. A clinical study of

motor evoked potentials using a triple stimulation technique. Brain. 1999 Feb;122

( Pt 2):265-79. PubMed PMID: 10071055.

7: Nielsen J, Petersen N, Crone C. Changes in transmission across synapses of Ia afferents in spastic patients. Brain. 1995 Aug;118 ( Pt 4):995-1004. PubMed PMID: 7655894.

8: Sinkjaer T, Toft E, Hansen HJ. H-reflex modulation during gait in multiple

sclerosis patients with spasticity. Acta Neurol Scand. 1995 Apr;91(4):239-46.

PubMed PMID: 7625147.

9: Toft E, Sinkjaer T. H-reflex changes during contractions of the ankle

extensors in spastic patients. Acta Neurol Scand. 1993 Nov;88(5):327-33. PubMed PMID: 8296530.

10: Feeney DM, Gold GN. Chronic dorsal column stimulation: effects on H reflex

and symptoms in a patient with multiple sclerosis. Neurosurgery. 1980

May;6(5):564-6. PubMed PMID: 6968046.

11: Illis LS, Oygar AE, Sedgwick EM, Awadalla MA. Dorsal-column stimulation in

the rehabilitation of patients with multiple sclerosis. Lancet. 1976 Jun

26;1(7974):1383-6. PubMed PMID: 59019.

I agree, reading old literature as above would be necessary.

As I recall, 10 V is too low an stimulus intensity for such human expts. Also, it might be possible to "play" with stimulus duration (need to be ~1 ms, I recall!).

Needs to change things around.

Good luck

KW

**Update: I have reassessed the location of stimulation which (luckily) corrected my problem. Many thanks for the articles Michael; a few of them I did not have in my collection.**