Sahay and colleagues (2007) speculate that neurogenesis in the dentate gyrus may mediate some of the behavioral effects of antidepressants. The dentate gyrus has also attracted attention in relation to Alzheimer's disease because of its resistance to the formation of plaques, tangles, and neuronal death (Ohm, 2007).
Dear Ricardo! Our group began to conduct research in this direction recently, but our papers are in print. We focus on the role of the functional state of smell and visual perception of space-in the development of Alzheimer's disease symptoms. Please see the two articles on the subject of your question (in the appendix).
Vladimir
Thanks Vladimir, I appreciate the papers. Congratulations to your team!
dear Ricardo,
Yes, we have. See our pubs below, should you need the pdfs, just let me know. Best,
Paul
1. Karin Boekhoorn, Marian Joels and Paul J. Lucassen. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease, 2006; 24(1):1-14.
Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Krugers H, Wiegert O, Ramakers GJ, Joels M, Van Leuven F, Lucassen PJ. Improved LTP and memory in tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. Journal of Neuroscience 2006; 26(13):3514-3523
2. Kristina Sennvik*, Karin Boekhoorn*, Reena Lasrado*, Dick Terwel, Steven Verhaeghe, Hubert Korr, Christoph Schmitz, Takami Tomiyama, Hiroshi Mori, Harm Krugers, Marian Joels, Hana Dawson, Ger J.A. Ramakers, Paul J. Lucassen and Fred Van Leuven. Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. FASEB J. 2007; 21(9):2149-61.
3. H. Georg Kuhn, Christi Cooper-Kuhn, Karin Boekhoorn and Paul J. Lucassen. Involvement of adult neurogenesis in dementia and Alzheimer mouse models; what is the functional relevance ? Eur. Arch. Gen Psy. & Clin. Neurosci., 57(5): 281-9, 2007.
4. Alyssa Thompson, Karin Boekhoorn, Anne-Marie Van Dam, and Paul J Lucassen. Changes in adult neurogenesis in neurodegenerative diseases; cause or consequence? Genes, Brain and Behaviour, 7 (Suppl. 1), 28–42, 2008.
5. R.W.H. Verwer, A.A. Sluiter, R.A. Balesar, J.C. Baayen, D.P. Noske, C.M.F. Dirven, J. Wouda, A.M. van Dam, P.J. Lucassen, D.F. Swaab. (2007) Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain, 130, 3321-3335.
6. Michael W. Marlatt, Jan Bauer, Eleonora Aronica, Elise S. van Haastert, Jeroen J.M. Hoozemans, Marian Joels and Paul J Lucassen. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plast. 2014: 693851. doi: 10.1155/2014/693851.
7. Marlatt MW, Potter MC, Bayer TA, van Praag H, Lucassen PJ. Prolonged Running, not Fluoxetine Treatment, Increases Neurogenesis, but does not Alter Neuropathology, in the 3xTg Mouse Model of Alzheimer's Disease. Curr Top Behav Neurosci. 2013;15:313-40
7. Marlatt MW, Potter MC, Lucassen PJ, van Praag H. Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Dev Neurobiol. 2012 Jun;72(6):943-52.
9. Paula van Tijn, Willem Kamphuis, MW Marlatt, Elly M. Hol, Paul J. Lucasssen. Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Progress in Neurobiology, Volume 93, Issue 2, February 2011, Pages 149-164.
10. Michael W. Marlatt and Paul J. Lucassen. Neurogenesis and Dementia: Biology and Pathophysiology of Mice and Men. Current Alzheimer’s Research, Vol 7(2), p. 113-125, 2010.
11. Carlos P. Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P. Boks, Caroline Biojone, Samia Joca, Harry W.M. Steinbusch, Katie Lunnon, PJ Lucassen, Diego Mastroeni, Jonathan Mill, Paul Coleman, Daniel van den Hove and Bart P.F. Rutten. Epigenetic regulation of adult neural stem cells. Implications for Alzheimer’s disease. Mol Neurodegener. 2014; 9:25. doi: 10.1186/1750-1326.
I have been gathered some information about neurogenesis in order to better understand how could some cognitive functions differ from others when declining and what those brain regions could help on this. So, what do they have that makes them so special?
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