Prenatal diagnosis is certainly possible from invasive fetal testing - CVS/amnio/fetal blood sampling- so the earliest would be from 11 weeks onwards. To date non-invasive diagnosis (ie using free fetal DNA in the maternal circulation) has been more successful for beta Thal than for Sickle although the technique is the same and refinement of the technique may allow better detection that has so far been reported.
Thanks for your answer. As you know, Sickle cell anemia as other hemoglobinopathies has a high prevalence in south Iran. Because of the risk of abortion in Invasive method and the number of women carrying affected fetus, it could be helpful for these women. I try to use Real time PCR for this purpose.
We have done mainly invasive prenatal diagnosis for sickle cell anemia. I agree that invasive procedures have risk of abortion- 1-2%. Risk of the disease is 25%. Noninvasive prenatal diagnosis is not in clinical practice till now.
We perform prenatal diagnosis for SCD routinely. 53% of the pregnant women in the parisian area are at risk for SCD. However, after geneting counselling, only about 12% of the couples-mothers do ask for it.