After treating a compound to my cells, I noticed that cells died in a way I have never seen before (see the attached image - panel A). I don't think its apoptosis (apoptosis look like panel B). Basically, a single huge vesicle contains cell fragments. Any idea based on the morphological features? Thanks very much for your insights.
It might be necroptosis, an induced necrotic type of cell death. If you could mention the cell type you used and the compound, I might be able to support this idea further. Necroptosis takes place faster compared to apoptosis. I have seen necroptotic cells after 2h of treatment. I hope that helps.
All the best,
Lazaros
I think Olena is on the right path. I believe this death is called oncotic necrosis. Looks like giant blebs are forming. Something is either preventing the primary Na/K pump from working or energy production is severely impaired.
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