I wish to know the latent tuberculosis models which could mimic the natural mode of infection.
try moxifloxacin or bedaquiline (TMC 207), as such no drug is available yet
Start with the literature:
Treatment of Latent Tuberculosis Infection
www.medscape.com/viewarticle/781500_6Cache
Animal Models. The most informative animal model of TB has been the murine model. Early murine studies focused on treatment of active disease, but Grosset ...
Animal models of tuberculosis - Young - 2009 -...
onlinelibrary.wiley.com
› …
› Vol 39 Issue 8
› Abstract
There is a wide range of animal models of tuberculosis; ... different aspects of human TB in a wide range of experimental animals Drugs Vaccines Latent infection
Animal models of tuberculosis - ScienceDirect.com...
www.sciencedirect.com/science/article/pii/S1472979205000697
As all existing animal models fail to mimic the ... The design of an adequate animal modelof latent M. tuberculosis infection is hampered by lack of knowledge about ...
What Animal Models Teach Humans about Tuberculosis...
www.atsjournals.org/doi/full/10.1165/rcmb.2008-0154TR
What Animal Models Teach Humans about Tuberculosis Volume 39, 5 (November, 2008) ... rabbits also serve as a model through which to study latent, ...
Models of Latent Tuberculosis: Their Salient...
www.ncbi.nlm.nih.gov
› …
› J Lab Physicians
› v.3(2); Jul-Dec 2011
... it is imperative to devise in vitro and models of latent tuberculosis to explore potential ... there are a number of in vivo animal models like ...
Animal Models of Tuberculosis - Animal...
www.sciencedirect.com/science/article/pii/B978012416002600002X
Animal models for tuberculosis research provide valuable and ... experimental mice can be used as an animal model for TB ... this latent TB model is ...
Animal models of tuberculosis. - National Center...
www.ncbi.nlm.nih.gov/pubmed/16249122
Animal models of tuberculosis. ... As all existing animal models fail to mimic the human disease ... as the alternative animal model for TB. ...
Animal models of tuberculosis - ResearchGate -...
www.researchgate.net/.../26734388_Animal_models_of_tuberculosisCache
Animal models of tuberculosis on ... of many animal models for tuberculosis ... of Mtb infection and potentially establishment of latent TB.
Treatment of Latent Tuberculosis Infection
www.medscape.com/viewarticle/781500_7Cache
Animal Models; Treatment; ... completion rates than 9H for treatment of latent M.tuberculosis ... in a murine model of latent tuberculosis ...
Tuberculosis: Latency and Reactivation
iai.asm.org/content/69/7/4195
ANIMAL MODELS. Studies of latent tuberculosis have been hampered by the lack ofanimal models truly representative of human latent tuberculosis.
My Dear Colleagues very good morning from Malaysia,
Dear Singh, are you treating LTB in your practising in India, as it is important for me. I am trying to access Indian TB treatment guideline and re-look.
While Pasquale Urbano did answer well.
If we start to treat LTB, it means we have to treat one third world population with reference to WHO...
Dear Collleagues,
the idea of treating LTB is biologically sound only in very low endemy settings, where a person with a raectivation of its LTB could spread TB to its unprotected contacts. True it is that such treatment is fraught with difficulties, firstly because the agent cannot be isolated and studied in vitro -- by definition.
In high endemy settings the persons who have encountered MTB and have recovered, perhaps without clearing the infection, the majority, LTB by definition, have a solid immunity against MTB, which is reinforced by repeated encounters with the agent. Their probability of getting TB by reactivation of their LTB is lower of the probability in a person without LTB. The Koch phenomenon, and its interpretation, still holds.
Control of TB in high endemy countries must follow the course that was successfull elsewhere: better living conditions, effective detection, treatment and isolation of new cases...
The latent and active Tuberculosis have same susceptibility to antimicrobial agents that depends on the susceptibility of infecting mycobacteria . The difference that latent Tuberculosis is treated according to certain criteria while the active one is always required treatment by antimicrobial agents.
You can check WHO recommendations on regimens and target groups for LTBI treatment in this link: http://www.who.int/tb/challenges/ltbi/en/. The guidelines also include evidence from the systematic reviews that you may find useful.
Dear Sir/Madam, see these links below may be useful for you.
1)The challenge of new drug discovery for tuberculosis - Nature
www.nature.com/articles/nature09657 Traduire cette page
de A Koul - 2011 - Cité 536 fois - Autres articles
27 janv. 2011 - In this review, we discuss innovations in TB drug discovery and evolving ... Reactivation of latent TB, even after decades of subclinical ...
2)Drug Targets in Mycobacterial Sulfur Metabolism
www.ncbi.nlm.nih.gov › ... › PubMed Central (PMC) Traduire cette page
de DP Bhave - 2007 - Cité 76 fois - Autres articles
The identification of new antibacterial targets is urgently needed to address multidrug resistant and latent tuberculosis infection. Sulfur metabolic pathways are ...
3)New insights on the nature of latent tuberculosis infection ...
www.ncbi.nlm.nih.gov/pubmed/17352686 - Traduire cette page
de PJ Cardona - 2007 - Cité 43 fois - Autres articles Inflamm Allergy Drug Targets. 2007 Mar;6(1):27-39. New insights on the nature of latent tuberculosis infection and its treatment. Cardona PJ(1).
You may get maximum information for ant-TB therapy and the target for it.
http://webs.iiitd.edu.in/raghava/antitbpdb/
Article AntiTbPdb: a knowledgebase of anti-tubercular peptides
- Badges
- Science topic