Holland AE, Hill CJ, Rasekaba T, Lee A, Naughton MT, McDonald CF. Updating the minimal important difference for six-minute walk distance in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2010;91(2):221–225. doi:10.1016/j.apmr.2009.10.017
Rasekaba T, Lee AL, Naughton MT, Williams TJ, Holland AE. The six-minute walk test: a useful metric for the cardiopulmonary patient. Intern Med J. 2009;39(8):495–501. doi:10.1111/j.1445-5994.2008.01880.x
All these references are very interesting. However, the MCID should be assessed for each population. An improvement of 25 meters has not the same clinical relevance in a severe COPD and in a diabetic 65 years old patient without other comorbidities. So, theres a lot of work to do. Anyone interested in address it? :-)