The answer is "Yes". Please see the following PDF attachments.

Cross talk occurs between tumor cells & micro-environmental stromal cells & immune cells

Thanks to all.

Thanks dear Ahmed,

Could You be more specific about this, please. What do you exactly mean by "cross talk". Could you possibly introduce me some good resources for this purpose.  

Dear Negin,

you can read

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

http://dx.doi.org/10.1016/j.stem.2015.02.015

Dear Negin,

Also, other more specific resources:

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity    

http://www.nature.com/nm/journal/v21/n5/abs/nm.3848.html

A cross-talk network that facilitates tumor virotherapy

http://www.nature.com/nm/journal/v21/n5/abs/nm.3857.html

Also, nice illustration at:

http://docs.abcam.com/pdf/cancer/tumor-microenvironment-and-the-immune-system.pdf

Thanks dear Ahmed,

Your resources are very helpful, but they are full of complicated biological material which is hard to understand for me as a computer science student. So, let me be clearer about my question.

First of all, I want to know if tumor cells learn some information by interaction with the environment. Secondly, I want to know if they share this learned information with each other. For example, do tumor cells learn to undergo necrosis or apoptosis in the case of low oxygen condition or do they learn to proliferate in the case of high level of oxygen by time passing?

Thanks Dear Negin,

Then, you like to know information about Metabolic effect on tumor cell state

So I recommend for you

Understanding the Warburg Effect:The Metabolic Requirements of Cell Proliferation

http://www.sciencepubs.com/content/324/5930/1029.full.pdf

If you find it helpful, tell me, I have many others, but, I don't want to overwhelm you with unnecessary information

or more direct link

http://hoffman.cm.utexas.edu/courses/warburg_effect_2009.pdf

Dear Ahmed,

I know about the Warburg Effect. The point is, I want to know whether the "cross talk" is about choosing a phenotypic behavior (Quiescence, proliferation, apoptosis, and necrosis) based on the environment (e.g., oxygen level).

Dear Negin,

http://www.tandfonline.com/doi/pdf/10.4161/cc.24479

or

http://www.medicinabiomolecular.com.br/sdi4/sdi4-arquivos/pdf/ca-4905.pdf

Bidirectional interconversion exists between non-CsC and cancer stem cell (CsC) cellular states.

Genetic determinants, epigenetics and extrinsic factors (niche), causally determines either “permissive” (P) or “non-permissive” (NP) features that lastly determine the number of additional requirements to gain the self-renewal capacity, potency and tumorigenicity possessed by CsC cellular states.

Tumor cells elevated glucose consumption is necessary, because carcinogenesis itself takes advantage of the elevated production of toxic glycolysis by-products, such as lactate.

Increased glucose consumption in invasive and metastatic lesions is not used

for substantial energy production (ATP) as is commonly assumed; rather, the glucose is used to produce acid, which gives the cancer cells a competitive advantage for invasion.

Because that cell division phenomenon requires substantial levels of cellular macromolecules, the bulk of the glucose cannot be committed to carbon metabolism for ATP production via mitochondrial OXPHOS.

Because the synthesis of nucleotides, amino acids and lipids consumes more equivalents of carbon and NADPH (nicotinamide adenine dinucleotide phosphate, reduced) than ATP, the conversion of all of the glucose to CO2 via mitochondrial OXPHOS to maximize ATP production will drastically impair the needs of a proliferating cell.

Then exogenous microenvironmental factors (e.g., hypoxia, oxidative

stress, extracellular matrix detachment and nutrient starvation) and intrinsic genetic determinants (e.g., oncogenes, tumor suppressor genes and

epigenetics) converge to coordinately determine the induced and/or inherent activation status of the Warburg phenotype in tumor tissues.

Recently Cancer derived Exosomes are discovered which has shown to be one of the important  tools used by cancer cells in cell - cell and cell - matrix interactions. It is a small membrane bound vesicle which contains Nucliec acids, proteins etc. It has variety of functions, like modulating immune system, providing prometastatic niche for cancer cells, helps in angiogenesis under hypoxic conditions. Please go through some of the attached articles. Hope this will help you.

Dear Negin

Ahmed and Vikash have given you Scientific view points; I would like to be nonSCientific and say that Cancer cells are crazy, they will tell neighboring cells also to go crazy, for no purpose

To be scientific again, I read long back (don't remember the reference) that even cell free filtrates from tumour cultures can turn other cells malignant, which means that even their word (contained in the solutions) harbour malignant potential

Narayanan

Dear Negin,

Cells, regardless of types are the "chattering classes ! They "talk" to each other through complex electrical signalling processes. The whole area of things like electrotaxis (migration of cells influenced by an electrical field) and the dynamics of cell process, such as aptosis, senecence ,equally due to electrical signalling, is a rather undersubscribed area. I

If you think about it, the act of reading this response requires your neurological system to send electrical signals from eyes to brain where many other cells will enable the words to make some sense (I hope); just to make it really complex these can be binary, essentially on/off, or analogue signals. Add to this the variation in electrical charge when ion gates open to admit sodium/potassium/calcium/phosphates.

Many if not all of the references give by respondents to your enquiry would be useful if you are able to devote sufficient time, however, as I stated, there is a lack of knowlege relating to the influence of electrical fields and cells, you may not get the definitive answer you were looking for !

I hope the above is of some use.

Regards. Tony Anson

The answer is "Yes". Please see the following PDF attachments.

Communication between cancer cells and the cells in the microenvironment is a two-way process that involves a wide variety of non-cancer cells and a diverse range of mechanisms. .

E.g: mesenchymal stem cells (MSC) which participate in many mechanisms in both solid tumors and blood cancers. They produce a wide variety of secreted proteins that can suppress immune surveillance, such as TGF-β, galectins, and various interleukin molecules. They can also produce cytokines and chemokines that can support cell growth and survival of the cancer cell. When a leukemia cell comes in contact with a MSC, cell adhesion promotes production of many survival molecules including anti-apoptotic BCL2 (B-cell lymphoma 2) family molecules in the leukemia cell. The mechanism can involve integrin-mediated signaling.

Kindly go through the link

https://www.cancernetwork.com/novel-targets/cell-cell-communication-tumor-microenvironment

Article Cell-to-cell communication in cancer: Workshop report

Article Brain Tumor Cells in Circulation Are Enriched for Mesenchyma...

Article Circulating tumour cells as prognostic markers in progressiv...

Article Reversion of the Malignant Phenotype of Human Breast Cells i...