Spermatogonial stem cells transplant to patient with primary or secondary (cancer survival) testicular failure may technically be feasible as studies in monkeys have confirmed regeneration of spermatogenesis after xenotransplantation to nude mouse (Herman et al Cell Stem Cell. 2012 11(5):715-26.) A group at University of Pittsburg (Orwig et al) have presented a model (ASRM 2013) that looks promising for use of stem cell for male fertility preservation in pre-adolescent boys!
The paper about the CMV & HSV being positive in the sample of the sperm is a very authentic evidence that causes the anatomical anomaly in the spermatoneogenesis, including but not limited to the aspermia. If you simply check your patients for the antibodies (IgG) present in the blood over the cut off value, that will lead you to determine the root cause of the aspermia, oligospermia, etc.
What we traced was as following.
1. The Neurons responsible of secreting the "Neuro Secretory Enzymes" (NSE) are inflicted with the CMV RNA proliferation, therefore, secreted with the NSE to stimulate the Pituitary. The molecular integrity of the NSE is compromised.
2. The pituitary stimulation by the compromised NSE in turn gives rise to the compromised stimulating hormones, including FSH and others.
3. Comes the arrival of the Neuro viral RNA into the testes along with the stimulating hormone.
4. A variety of sperm reproductive anomalies take place.
Best Regards.
Prof. Shahid H. Sheikh,
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