Do you use antifoam in vehicles for oral gavage of mice?

05 May 2014 1 942 Report

I want to orally administer a drug to mice, and according to the literature the drug needs to be dissolved in a vehicle containing 1% sodium carboxymethylcellulose, 0.5% sodium lauryl sulfate, and 0.05% antifoam. All the papers using this inhibitor do however not mention what type of antifoam they use in their vehicle.

So, can you recommend an antifoaming agent for an oral vehicle for mice?

Thank you

Freja Venning

I found out that antifoam is not necessary with this low concentration of SDS, no bubbles form if you're careful when you make and administer the vehicle.

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