I am characterizing some neurons that seems to respond to SLIGRL-NH2. I would like to purchase some antagonists GB83 and/or GB88. It would be great if someone could let me know the sources from which I can purchase these reagents. Thanks.
Dear Zongyou Guo,
You may not find any source for purchasing GB83 or GB88.
Gb88 was sythesized by JY Suen et al. (Australia), however, in their published paper (see below) they did not report the procedure for GB88 synthesis.
You may contact them and get some quantity of the compound or the synthetic procedure.
Br J Pharmacol. 2012 Mar; 165(5): 1413–1423.
doi: 10.1111/j.1476-5381.2011.01610.x
PMCID: PMC3372726
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
JY Suen, GD Barry, RJ Lohman, MA Halili, AJ Cotterell, GT Le, and DP Fairlie
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
David Fairlie, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld Q4072, Australia. E-mail: [email protected]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372726/
Hoping this wil be helpful,
Rafik
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