Do you know anything about possible interactions between proline and mGluR5 glutamate receptor ? I have found that proline interferes with other glutamate receptors, but nothing about mGluR5, but it is possible because I am moving in a field where I do not have sufficient confidence.
Eg... These results suggest that endogenous extracellular proline regulates the basal function of some glutamate synapses by maintaining them in a partially potentiated state... and more
However, do you think that "bona fide" can this also be possible for mGluR5 glutamate receptor ? It would be interesting to know if in mice, generated for this work, there is some anomaly in the proline and glutamate metabolism.
All this for the intriguing and elegant article reported here
Article MGluR5 Modulation of Behavioral and Epileptic Phenotypes in ...
https://www.researchgate.net/post/Does_anyone_know_anything_about_the_metabolism_of_proline_in_Tuberous_Sclerosis
I thank you very much Jay, however regardless of proline-rich proteins that are definitely involved in these processes I think instead of free proline whose metabolism seems to be altered in tuberous sclerosis. Other proline-rich proteins are somehow related to tuberous sclerosis lesions, eg Akt, SFPQ etc. but I do not know and I do not think this is the source of the possible increase of free proline in TS lesions, on this possibility I do not I have the possibility of judgment.
Article Structure of metabotropic glutamate receptor C-terminal doma...
Thank you Mohammed for this interesting article, but I still think about free proline. Eg with mechanisms like those described in this article with an involvement of PAT1 (SOLUTE CARRIER FAMILY 36 (PROTON / AMINO ACID SYMPORTER), MEMBER 1; SLC36A1; LYSOSOMAL AMINO ACID TRANSPORTER 1; LYAAT1; PROTON / AMINO ACID TRANSPORTER 1; PAT1)
Article Nutrient Signaling to mTOR and Cell Growth
probably as happens in plant galls that I believe to be the result of an overactivation of TOR and / or related proteins.
Article Changes of metabolites status in plant pathogen interaction
https://www.researchgate.net/post/Is_TOR_Target_Of_Rapamycin_overactive_in_plants_galls
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