We are starting the research concerning the prognostic significance of immune profile in HPV carcinogenesis.
Dear Erik Kudela!
Hier is the possible answer, following with the recent article!
Sincerely Yours!
Dr. Bratko Filipič
E-mail: [email protected]
Available data indicate that cervical cancer develops through infection to preinvasive lesions to invasive cancer, a process that on average takes decades[8]. However, the molecular mechanisms involved in the development of a persistent HPV infection resulting in the development of cervical cancer are not well-established. Host innate immunity and adaptive immune response all are responsible for the regression, persistence, or progression of HPV infection. For example, a polarization of the immune response for T-helper 2 (Th2) was observed in women with HPV infections that evolve into high-grade lesions[9], whereas squamous intraepithelial lesions and in situ carcinomas evading immunological control seem to be influenced by the cellular antigen presentation system and the HLA receptors[5]. The transcriptional blockage of the HPV DNA also facilitates the malignant transformation caused by HPV persistent infection, and in this case, the tumor necrosis factor-α (TNF-α)-mediated cascade plays an important role[5].
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