Hi,

To measure the liver volume accurately:

For your qeustion, kindly see the following link

http://onlinelibrary.wiley.com/doi/10.1002/lt.500020606/pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874039/

http://www.wjgnet.com/1007-9327/5/525.pdf

http://www.barriosybarrios.com.ar/webmail/system.asp?p=22

I really appreciate your quick response, Dr. Vasudevan. The information you provided is helpful, however, is there any other possible ways of measuring liver volume, besides CT and MRI? 

Carefully excise the entire liver and immerse it in a measuring cup filled with certain amount of physiological saline. Record the volumes before and after immersion and the difference is the volume of the liver. Very accurate! Good luck!

Thanks for the suggestion. That is a good way, however, the problem may be the accuracy itself. For one thing, the appropriate scale and the size of the measuring cup should be considered carefully while doing this (the liver of mouse is really small; if we want to measure some changes of liver volume, it is hard to choose the measuring cup. Normally, changes are within 20-50 uL). Additionally, when you record the volumes before and after immersion, there should be some errors (which is associated with the minimal scale of the measuring cup). How to solve these problems?

I am using animal CT scans to very accurately measure rodent liver volumes. Why no use that?

I understand that he is seeking a "relatively cheap and convenient way".

O.k.Got it. Just think all other methods are less exact, in my opinion.

Erik

Reply to Dr. Erik: Thanks for your suggestions. Animal CT scan or MRI is a good way to measure rodent liver volumes, but I just want to check any possibilities besides these methods.