What is your question?

Hi Bill. 

Do you work in commercial clinical proteomics laboratory based on LC-MS/MS method? 

I just curious,  is it possible for now to provide diagnostics service (proteomics)  using LC-MS/MS methods?  From literature,  we just know that some diseases give different biomarker concentration, but can we use those data to tell patient condition and which treatment is suitable for them? 

If you or anybody else is working in commercial clinical proteomics laboratory based on LC-MS/MS method,  I hope you willing to have some discussion with me.  

Hello Aisyah: I am a professional consultant in analytical instrumentation techniques and especially medical applications. Many of my clients are working on developing fast, efficient LC-MS/MS methods for the quantitation of biomarkers in human serum and/or spinal fluids. Many clinical methods have been developed over the past ten years, but we still have a long way to go before they will be selective enough, accurate and cost effective to provide a wide range of diagnostic capabilities. The number is small so far.

If you perform a keyword search on the web, you will find hundreds of examples of methods used for all kinds of diseases and pathologies (e.g. pancreatic cancer, diabetes ....). Due to different regulations, some can not be used in a patient environment as they are still considered at a research stage, but this is changing each year as new methods are developed. So, to answer your question, yes, it is now possible to use LC-MS/MS methods to provide some types of diagnostic services.

Thanks Bill for your answer. :)