We know that there are lot of antioxidant topical creams in the market. These antioxidant help to reduce the radicals and prevents for oxidative stress and aging. But I am confused whether these antioxidants act on surface of skin or it need to penetrate into the skin (stratum corneum) to act. Anyone aware about this can help me out. Thanks in advance.
Thanks for sharing, The ncbi journal don't have the assess for full version. But couldnt able to get the clear answer for it.
Anyway thanks for your response.
Hi
antioxidants act on living cells to react with the free radicals produced during metabolic processes and prevent cell damage and aging. So, in order to act it must penetrate the dead cells of stratum corneum to reach the living cells in the subcutaneous tissue, and the different topical formulas differ in their ability to penetrate the rate -limiting step of the st. Corneum to deliver these antioxidant (differ in molecule size and nature) to the living cells of skin
Regards
Hi Nashwan, First of all thanks for your reply.
Generally topical creams have skin penetrats but if we use skin penetrats there is a chance that it may enter the systemic circulation also.
If we need the surface phenomenon beneath the Stratum Corneum are you aware which penetrant that can be used to reach the subcutaneous tissue without reaching the systemic circulation? My molecule is Resveratrol and the molecular size is big and needs a penetrant but unaware hw it can be held in subcutaneous tissue without reaching the systemic circulation and hw to check it invitro in the lab without doing invivo studies.
Can you share if you have idea in this?
Dear Ramkumar
I think it depends on the physics-chemical properties of the Resveratrol including the polar groups and the number of active binding sites and the pKa and the affinity to bind different organic molecules that determines the extent of penetration because the penetration enhancers in general helps to cross the epidermis ,but later , it depends on the drug molecule itself and it's concentration in the preparation whether to stay locally or reach systemic circulation. You may need some literature survey concerning the molecule. You can check using excised animal skin to find extent of diffusion using Franz diffusion cell. Any way your API is natural and non toxic even if small concentration is found in blood
regards
Thanks Nashwan & Hosam for your reply
My drug is natural and it will not create any problem if it gets absorbed into systemic circulation. I thought to improve the therapeutic response of the topical cream on its application.
As rightly pointed out I need find the physico-chemical properties of Resveratrol and its penetration and will try to find that.
I will try to get it done using penetration cell enhancer.
If any of one could find any other additional details I will be great to hear.
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