I interest in DNA HPV and pre cervical cancer lesion , my questions?
1. method with DNA HPV hybrid capture 2, if cytology is LSIL and biopsy is CIN-1, the results is negative before and after cryotherapy, are there etiology other than HPV or are false negative?
2. method with DNA HPV hybdrid capture 2 , after cryotherapy and CIN 2+ , DNA HPV negative , can it be false negative?
These are very unlikely to be HPV false negatives. There seem to be many other infections, not causal for cervical cancer, for which no treatment is required (they resolve spontaneously).
1. Most likely you are dealing with LSIL associated with low risk HPV types. I am not keen on cryotherapy. Just follow the patient!
2. CIN2 ideally, should be triaged with p16 - some of it will be just LSIL or even metaplasia. True HSIL can also be HPV negative - with potential implications in the follow up. Although it is not incorrect, I do not support treating high grade disease with cryotherapy.
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