Distinction of protein

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Pallavi Sabharwal

By similar protein you mean identical Molecular weight because even if these proteins have identical Molecular weight,by the difference of their shape that is either fibrous or globular you can still go for gel filtration chromatography as they will elute at different times.

Szymon Kurdyn

A classic: already tried 2d-gelelectrophoresis? Using 2 different characteristics of the protein at the same time (isoelectric point and "size") maybe you get a separation.