Hello

I have been getting great support from RG members.

Today, i want to ask about phosphorylation.

LATS1, which is known to be a critical component of Hippo pathway,

regulates YAP. As far as i know negative regulators of Hippo pathway

enhances nucleus localization of YAP by inhibiting LATS1.

Here is my question : LATS1 has phosphorylation sites.(S909 and T1079)

I studied that increased phosphorylation at such sites indicates elevated activity of LATS1, affecting loclization of YAP inside cells.

Is there any critical difference between the affect of dephosphorylation of

S909 and T1079 of LATS1? I have heard that phosphorylation or dephosphorylation at different sites in one same molecule can have different effects, which makes related research quite tricky and complex.

I want to know whether such differences exists in LATS1, as i just described above.(ex) Same YAP nucleus translocation but different target gene expression, etc.)   

Thank you for your interst and hope for your great achivements in your research