Differences between bioaerosol tests on viral suspension and purified virus RNA suspension?

06 October 2020 1 3K Report

Hi, I'm trying to execute a bioaerosol test on an RNA virus in order to estimate the inactivation rate after exposition with UV radiation, and for safety reasons, I would like to proceed to aerosolize a purified RNA suspension of the virus. There are considering differences confronting the results obtained using directly the aerosolized virus and the aerosolized virus RNA suspension?

William A. Anderson

RNA alone in aerosols will quite likely have different UV degradation kinetics than the effects of UV on RNA enclosed within a virus particle in aerosols. It might be interesting to try for testing your experimental methods, but the results would not be directly relevant to virus inactivation.

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