Well, I think the question is too general, and consequently it doesn't have a specific answer. Why? Because current vaccine projects are in different stage of research and development. If one vaccine candidate is supported by a number of well founded studies and experiments, showing their safety and an acceptable level of immunological titles, the answer is yes. Otherwise is reasonable to wait for more evidences.
That's my point, at least based on what I understood.
There have already been many questions on this topic. I answered them in detail. If the opinion is important here Yes / No. I will answer YES. If you have questions for me with the organizing of the answer, write, I will answer you
Dear Professor @Mutasem Z. Bani-Fwaz, (in lighter vein) this is a question of life or death.
In my opinion, the vaccines come after lot of tests/ trials. But, there will be always a risk ( virus is mutating/ individual's response to vaccine may vary). So. I will get vaccinated.
Well it depends if they a secured, tested vaccine at my disposal:
1) Asher Mullard (2020). How COVID vaccines are being divvied up around the world - Canada leads the pack in terms of doses secured per capita. News Nature Open Access:
2) David Cyranosky (2020). Why emergency COVID-vaccine approvals pose a dilemma for scientists -Immunizations are speeding towards approval before clinical trials end, but scientists say this could complicate efforts to study long-term effects. Nature 588, 18-19 (2020) News, Open Access:
4) Susanne H Hodgson et al. (2020). What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2, THE LANCET Infectious Diseases, Open Access:
Primary efficacy analysis demonstrates BNT162b2 to be 95% effective against COVID-19 beginning 28 days after the first dose;170 confirmed cases of COVID-19 were evaluated, with 162 observed in the placebo group versus 8 in the vaccine group. Efficacy was consistent across age, gender, race and ethnicity demographics; observed efficacy in adults over 65 years of age was over 94%. Safety data milestone required by U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) has been achieved. Data demonstrate vaccine was well tolerated across all populations with over 43,000 participants enrolled; no serious safety concerns observed; the only Grade 3 adverse event greater than 2% in frequency was fatigue at 3.8% and headache at 2.0%. https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine
Moderna vaccine efficacy against COVID-19 has shown 94.1%; vaccine efficacy against severe COVID-19 was 100%. “This positive primary analysis confirms the ability of the vaccine to prevent COVID-19 disease with 94.1% efficacy and importantly, the ability to prevent severe COVID-19 disease.
mRNA-1273 continues to be generally well tolerated; no serious safety concerns identified to date https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-primary-efficacy-analysis-phase-3-cove-study
Of course, vaccines are manufactured to be safe and protect the population, the lack of vaccination in the last years have seen the return of many deadly diseases that had been erradicated through vaccination.
There must be an initiation. In these trials so far no significant adverse effects reported except for allergic reaction with out significant morbidity.
I will receive the vaccine when I can. Of course, the initial roll-out of limited quantities of vaccines that are still investigational, but will provide the opportunity to ethically obtain pivotal data to improve regulatory and public health decision making, thereby increasing public and professional confidence in these and other vaccines.
There are also exceptional reasons why certain groups of people should not receive the vaccine according to the guidelines such as pregnant women, younger than 16 years old individuals, people with a severe allergic reaction, people who have a history of Bell's palsy, and Guillain Barre Syndrome.
there are still many unknown items in the vaccine application.
First, there are different types of vaccines, so you should select which will be the best for you.
The Vector vaccines (Sputnik and AstraZeneca) could be used only once, because the vector (the antigen transporter) will also induce antibodies formation in the host. The vector is an adenovirus, probably, if somebody has had the adenovirus infection his result of vaccination will be poor, because the preexisting antibodies will work against this vaccine.
The Moderna and Pfizer are ARN vaccines, seemingly very good ones. But the humans never have got heterogeneous ARN parenterally. What complications could appear at a long time? As we know, the reaction between ARN and host response could stimulate autoimmune diseases in some persons prone to such disorders.
The best vaccines will be the SARS virus attenuated or killed. They are in the process of manufacturing, because requiere more time to test and produce them.
I won't. It was only shown that the vaccine should work. It's very unlikely for someone of my age to get really ill. I don't need a vaccination for security. 80+-people do.
But there are 2 other important factors: 1. sterile immunity and 2. long-term effects.
1. It wasn't shown that the vaccines can break infection chains. The only reason i should take it.
2. Because Phase 1 and 2 were combined to 1/2 the observation period is indeed very very short. Because i'm so young i want to be sure, i that i will not suffer from this effects for the next 50 years.
There are some more problems/reasons, but these are the main reasons.
Vaccine trials take a considerable period of time to prove efficacy. However it is everyone's responsibility to cooperate and find remedy in this pandemic situation. Thus good to get the vaccine as a front liner