Are there molecules that could be more unstables at -80º C than -20º C.

If there is anyone with this behaviour, which is the reason?

I can only think in biomolecules like proteins that have determined tridimensional structures that can be lost by means of lowering the temperature. Temperatures extremely low provoque more rigid structures and some weak bounds that maintain the spatial structure could be broken.

Anybody could give examples and/or other explanations