Hi!
I would need to clarify overall the interactions between both the cholinergic and GABAergic systems. I read about an increased release of GABA in the striatum following an anticholinesterase agent challenge. Any other ideas? Data?
Thank you!
Fiona
Yes, acetylcholine released from interneurons in the striatum can excite GABAergic interneurons through nicotinic receptors or M3 receptors, but can also inhibit GABA release through M4 receptors (see the links for references). For interactions in the cortex, Blandina has studied this system a lot and has a good review in J Physiol Paris. 1998 Oct-Dec;92(5-6):351-5. Also, GABAergic neruons from the VTA and septohippocampal pathways modulate ACh release to affect memory and learning (for examples, see Front Behav Neurosci. 2014 Jan 22;8:8. doi: 10.3389/fnbeh.2014.00008, J Neurosci. 2014 Jan 8;34(2):506-14. doi: 10.1523/JNEUROSCI.2352-13.2014, and Cereb Cortex. 2014 Aug;24(8):2093-107. doi: 10.1093/cercor/bht060).
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21550798/
http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=12151512
nAchR have been found to promote GABA release in Layer V of mouse prefrontal cortex http://cercor.oxfordjournals.org/content/20/7/1539.short
Also Liu and coworkerk highlighted how nAChR activity can alter synaptic remodelling during early postnatal life affecting GABAergic signalling
http://www.sciencemag.org/content/314/5805/1610.short
In our lab we're working on this topic trying to understand if nAchR mutation can promote epilepsy through this kind of mechanisms.
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