Hi Felipe,

Impairment of PPI is thought to be a measure of sensorimotor gating deficits, which appears to be also impaired in several neurological and psychiatric diseases (e.g. schizophrenia, Alzheimer, etc.). However, there is no robust evidence suggesting consistent relationships between lower levels of PPI and higher levels of specific symptoms of schizophrenia such as positive or negative symptoms scores. Similarly, no relationships between acoustic PPI and working memory as well as other formal indices of neurocognitive function, have been detected among schizophrenia patients (e.p., Swerdlow wt al. Psychopharmacology 2009, 199(3):331). It is my suspect that, by now, PPI models would rather be useful to evaluate mechanism involved (or thought involved) in antipsychotic effects (p.e., D2 antagonism, serotonergic, cholinergic, NMDA, etc.) than to evaluate specific effects of schizophrenia simptomatology of antipsychotic drugs.

Regards,

Jordi S

Hi Felipe,

Impairment of PPI is thought to be a measure of sensorimotor gating deficits, which appears to be also impaired in several neurological and psychiatric diseases (e.g. schizophrenia, Alzheimer, etc.). However, there is no robust evidence suggesting consistent relationships between lower levels of PPI and higher levels of specific symptoms of schizophrenia such as positive or negative symptoms scores. Similarly, no relationships between acoustic PPI and working memory as well as other formal indices of neurocognitive function, have been detected among schizophrenia patients (e.p., Swerdlow wt al. Psychopharmacology 2009, 199(3):331). It is my suspect that, by now, PPI models would rather be useful to evaluate mechanism involved (or thought involved) in antipsychotic effects (p.e., D2 antagonism, serotonergic, cholinergic, NMDA, etc.) than to evaluate specific effects of schizophrenia simptomatology of antipsychotic drugs.

Regards,

Jordi S