Goal: Deadline for manuscript submissions: 28 February 2021 Dear Colleagues, Metal–organic frameworks (MOFs) have attracted a significant amount of interest from researchers in a broad range of scientific disciplines. Their compositional and structural diversity and porous character, with a large surface area to mass ratio and volume, enable them to be used in many applications, including gas storage, catalysis, biomedical, sensing, and energy-related applications. MOF-derived structures at the nanometre scale (NMOFs) can be synthesized by choosing appropriate organic ligands and metal ions and have been shown to enhance the performance of drug nanocarriers and provide gas sensors with high sensitivity. Progress has been made in designing tailored NMOF structures and tuning their morphologies. However, the shaping and engineering of these porous materials remain major challenges and we still need to improve our understanding of the relationship between their performance and morphology. This Special Issue aims to present an overview of new advances in the preparation and surface engineering of size-controlled nanoscale MOFs. In addition to synthetic aspects, the scope of this Special Issue covers a broad range of applications, including nanomedicine, catalysis, gas storage, and sensors. Contributions in the form of original research articles, review papers, and short communications are welcome. Prof. Dr. Antonio Vargas-Berenguel Dr. Juan M. Casas-Solvas Guest Editors https://www.mdpi.com/journal/nanomaterials/special_issues/MetalOrganic_frame Keywords - Metal Organic Frameworks - Sensors - Nanocarriers - Catalysis - Nanoreactors - Drug Delivery - Gas storage - Functionalized MOFs - Nanoparticles - Storage - Porous materials - Removal