The differentiation and proliferation of ESC (embryonic stem cell) are simultaneously occur during embryonic development. However, it is still unclear about the Chronological Order of hematopoietic stem cell self-renewal, differentiation, and proliferation.
In general, the HSC division(asymmetric or symmetric self-renewal division) takes precedence over proliferation.
Many questions are still unknown:
1, if yes. so why dose cell division of proliferation in HPCs precedes lineages commitment of differentiation?
2,Differentiation and proliferation of HSCs are independent or dependent processes?
3, The role of cell cycle phase among HSC division and proliferation.
Why do progenitors prefer to make cell fate decisions in the G1 phase rather than in other cell cycle phases ?
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