About Ch.11 position in the nucleus, relation of its territories to others, relation to nuclear membrane, its relation to nucleoskeleton or cytoskeleton that gives this Ch. a special character?
You have to be more detailed in your question if you want to get a good answer. Why would chromosome 11 be specific?
There are 2 major studies that determined the position of all chromosome territories in human cells. Do keep in mind that these studies only reflect the situation in these cell types:
Hi Daan, You're right. I did a type of nanoscale mechanical stimulation on human MSC. The microarray results showed significant genetic changes and most of the genes were located on Ch.11. We're following the theory of mechanical transfer of stimuli to the nucleus and nucleus vibration as the cause. Although Ch.1 is the prominent chromosome in the number of affected genes but when you calculate the known gene/chromosome length ratio, Ch.11 is on top then Ch.4 and 5. Because of these conclusion I'm looking for a clue about CH.11. I had seen one of the articles that you've sent before. Thank you for your reply and waiting for any new idea : )
That's a topic I'm not very familiar with. If you're purely considering the the number of affected genes/chromosome length though: keep in mind that chromosomes have hugely different gene densities, and that this influences the nuclear position of the CTs: http://jcb.rupress.org/content/145/6/1119.abstract
Thank you Dann. Any idea about nano vibration of nucleus? I found an increase in size and number of nucleoli after stimulation as well. It was with generalised decrease in intensity of chromatin. I'd like to know your view. Please have a look to this: http://www.ncbi.nlm.nih.gov/pubmed/22448380
Sorry, I have no experience with nano vibrations, so I can't say much there. The paper you link to I can't access, so same thing there. It seems a bit of a repeat of the Bolzner paper though.